Figure 1. Filamentous influenza virions are lost on laboratory passage.
Filamentous influenza virions are clearly visible after two passages of the clinical isolate influenza A/Rockefeller Institute/1/1957 (H2N2) virus in embryonated chicken eggs (a) but are lost following twelve passages (b). Electron micrographs © Choppin et al., 1960.
Originally published in THE JOURNAL OF EXPERIMENTAL MEDICINE. 112:945-52.