Fig. 5. Location of polar residues in TM helices in the Y4 (left) and Ste2p (right) receptors. Models of the Y4 (A) and Ste2p (B) receptors. Atoms of side-chains of polar residues in TM helices at least 6 residues away from the helix ends are depicted as spheres. TM1 and TM2 are colored in red, TM3–TM7 in light blue. (C) Single NMR conformers of TM12 from the Y4, and (D) the Ste2p receptors along with the surface potential of TM12 of Ste2p. Positively and negatively charged surfaces are color coded in red and blue, respectively.
