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Integration of dose-response data with multiple Adverse Outcome Pathways (AOPs) and one single Aggregate Exposure Pathway (AEP). The concentration of one stressor at its target site of action (i.e., target site exposure; TSE) can potentially link to several molecular initiating events (MIEs) that lead to different adverse outcomes (AOs) upon perturbation of the molecular targets, provided the TSE is sufficient to eliciting a specific MIE.
