Table 1.
Diverse structural features of ultralong CDR H3 Fabs
| Fab (PDB ID) | CDR H3 AA length | Protrusion distance (Å)a | No. Cys (disulfide patterns) | Stalk length (residues pairs)b |
|---|---|---|---|---|
| BLV1H12 (4K3D) | 61 | 41 | 6 (1–4, 2–6, 3–5) | 12 |
| BLV5B8 (4K3E) | 56 | 36 | 6 (1–3, 2–4, 5–6) | 12 |
| E03 (5IJV) | 44 | 37 | 2 (1–2) | 12 |
| B11 (5IHU) | 63 | 36 | 8 (1–4, 2–7, 3–8, 5–6) | 8 |
| A01 (5ILT) | 61 | 32 | 6 (1–4, 2–5, 3–6) | 8 |
a
Approximate distance from the tips of CDRs L1–L3, H1, H2 to the distal tip of the H3 knob
b
Length of hydrogen-bonded stalk domain in residues pairs (the number of amino acids forming the two-stranded β-ribbon divided by two)