Table 3.
Experimental runs, independent variables, & measures responses of 32 full factorial experimental designs of the formulated LPNPs.
| Runs | X1 | X2 | %EE | PS (nm) | %CDR |
|---|---|---|---|---|---|
| LPNPs-1 | 0 | 0 | 56.42 ± 0.43 | 220.8 ± 2.3 | 68.02 ± 0.42 |
| LPNPs-2 | 0 | −1 | 54.32 ± 0.09 | 218.9 ± 4.0 | 66.62 ± 1.32 |
| LPNPs-3 | 0 | +1 | 53.29 ± 0.30 | 216.5 ± 1.9 | 67.4 ± 0.46 |
| LPNPs-4 | −1 | 0 | 67.17 ± 0.36 | 206.7 ± 4.2 | 71.02 ± 0.6 |
| LPNPs-5 | −1 | −1 | 65.39 ± 0.33 | 201.1 ± 2.9 | 78.02 ± 0.62 |
| LPNPs-6 | −1 | +1 | 62.75 ± 0.61 | 197.5 ± 3.5 | 79.89 ± 0.86 |
| LPNPs-7 | +1 | 0 | 70.7 ± 0.56 | 189.8 ± 2.0 | 86.1 ± 0.72 |
| LPNPs-8 | +1 | −1 | 72.34 ± 0.23 | 178.6 ± 3.7 | 89.72 ± 0.21 |
| LPNPs-9 | +1 | +1 | 69.25 ± 0.27 | 200.3 ± 3.6 | 77.25 ± 0.61 |
Data represent mean ± SD of 3 determination.
Independent variable; X1 = Concentration of soya lecithin, X2 = Concentration of polymer, the level of independent variable were set at 0, -1, +1 i.e. lower, middle, and higher.
Dependent variable; %EE = entrapment efficiency, PS = particle size, %CDR = cumulative drug release.