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. Author manuscript; available in PMC: 2018 May 4.
Published in final edited form as: Cancer Res. 2017 Dec 27;78(5):1127–1139. doi: 10.1158/0008-5472.CAN-17-1453

Figure 2. Addition of CPI-455 to DAC treatment results in increased expression of DAC regulated genes.

Figure 2

A. Expression changes after exposure to CPI-455 as compared to CPI-203. B. Expression changes after exposure to DAC as compared to mock. C. Expression changes (relative to mock) at all DAC upregulated genes. D. Cumulative fold expression change for genes in (C) relative to DAC for DAC+203 & DAC+455 (**=p<.001, Kolmogorov-Smirnov test). E. Expression changes (relative to mock) at all methylated CpGi DAC upregulated genes. F. Validation of microarray data at panel of 4 genes. Expression for each gene was measured by qRT-PCR. M indicates that the gene has hypermethylated, CpG island containing promoter. G&H. GSEA analysis for Interferon Response gene set (from Li et al. (26)) in either CPI-455 relative to CPI-203 (G) or DAC+455 relative to DAC+203 (H). I. Expression of 8 ERV elements as measured by qRT-PCR.