Skip to main content
. Author manuscript; available in PMC: 2018 May 4.
Published in final edited form as: Cancer Res. 2017 Dec 27;78(5):1127–1139. doi: 10.1158/0008-5472.CAN-17-1453

Figure 3. Combination treatment does not result in further DNA demethylation relative to DAC alone.

Figure 3

A&B. Density plot of beta values (an estimate of methylation levels using ratio of methylated probe intensity and overall intensity) for MCF-7 cells exposed to DAC +/− KDM5i using either all probes (A) or only CpGi probes near TSS (B). C. Delta beta values for all CpGi TSS probes (in black) in CPI-455 (y-axis) and CPI-203 (x-axis) relative to mock. Probes corresponding to CPI-455 upregulated genes highlighted in red. D. Delta beta values for all CpGi TSS probes (in black) in DAC+455 (y-axis) and DAC (x-axis) relative to mock. Probes corresponding to DAC upregulated genes highlighted in red. E. Delta beta values for all CpGi TSS probes (in black) in DAC+455 (y-axis) and DAC+203 (x-axis) relative to DAC. Probes corresponding to DAC upregulated genes highlighted in red.