Table 3.
Univariate Association of EGFR, HER2, HER3 and PD-1, PD-L1, PD-L2
| PD-1+ lymphocytes in tumor | |||||
|---|---|---|---|---|---|
| Covariate | Statistics | Level | 0–1 N=33 | 2–4 N=57 | P-value* |
| EGFR average overall | N (Row %) | <= median (0.8) | 17 (39.53) | 26 (60.47) | 0.5 |
| N (Row %) | > median (0.8) | 14 (32.56) | 29 (67.44) | ||
| HER2 average overall | N (Row %) | 0 | 23 (33.82) | 45 (66.18) | 0.505 |
| N (Row %) | 0.025–0.3 | 8 (42.11) | 11 (57.89) | ||
| HER3 average overall | N (Row %) | <=median (0.1625) | 19 (44.19) | 24 (55.81) | 0.116 |
| N (Row %) | >median (0.1625) | 12 (27.91) | 31 (72.09) | ||
| PD-1+ lymphocytes in peritumoral stroma | |||||
| Covariate | Statistics | Level | 0–1 N=11 | 2–4 N=79 | P-value* |
| EGFR average overall | N (Row %) | <= median (0.8) | 6 (13.95) | 37 (86.05) | 0.747 |
| N (Row %) | > median (0.8) | 5 (11.63) | 38 (88.37) | ||
| HER2 average overall | N (Row %) | 0 | 8 (11.76) | 60 (88.24) | 0.699 |
| N (Row %) | 0.025–0.3 | 3 (15.79) | 16 (84.21) | ||
| HER3 average overall | N (Row %) | <=median (0.1625) | 6 (13.95) | 37 (86.05) | 0.747 |
| N (Row %) | >median (0.1625) | 5 (11.63) | 38 (88.37) | ||
| PD-L1 | |||||
| Covariate | Statistics | Level | 0 N=69 | 1–130 N=23 | P-value* |
| EGFR average overall | N (Row %) | <= median (0.8) | 38 (84.44) | 7 (15.56) | 0.061 |
| N (Row %) | > median (0.8) | 29 (67.44) | 14 (32.56) | ||
| HER2 average overall | N (Row %) | 0 | 51 (73.91) | 18 (26.09) | 0.770 |
| N (Row %) | 0.025–0.3 | 16 (80) | 4 (20) | ||
| HER3 average overall | N (Row %) | <=median (0.1625) | 34 (77.27) | 10 (22.73) | 0.622 |
| N (Row %) | >median (0.1625) | 32 (72.73) | 12 (27.27) | ||
| PD-L2 | |||||
| Covariate | Statistics | Level | 0 N=31 | 1–130 N=51 | P-value* |
| EGFR average overall | N (Row %) | <= median (0.8) | 15 (41.67) | 21 (58.33) | 0.686 |
| N (Row %) | > median (0.8) | 16 (37.21) | 27 (62.79) | ||
| HER2 average overall | N (Row %) | 0 | 22 (36.07) | 39 (63.93) | 0.520 |
| N (Row %) | 0.025–0.3 | 8 (44.44) | 10 (55.56) | ||
| HER3 average overall | N (Row %) | <=median (0.1625) | 13 (36.11) | 23 (63.89) | 0.755 |
| N (Row %) | >median (0.1625) | 17 (39.53) | 26 (60.47) | ||
*
The p-value is calculated by chi-square test or Fisher’s exact, where appropriate.