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The REV1 machinery for DNA damage tolerance and mutation. PCNA (homotrimer, green) is K164-monoubiquitinated (yellow) (UbPCNA) when a large DNA lesion such as a DNA crosslink is detected on the replication fork. REV1 (orange) has UBMs and binds to the UbPCNA. REV1 also binds to REV7 (wine red), recruiting REV3L (blue), which engages DNA replications that induce mutations (red arrowhead).
