Table 3.
Other genetic variants associated with methadone metabolism
| Ethnicity | Measurement | Gene | Alleles/ variants |
MAF (minor allele)a |
Finding | Referenc |
|---|---|---|---|---|---|---|
| Han Chinese (n = 321) | Dose | DRD2 | rs1799978 | 20% (C) | Minor allele carriers required lower doses | [34] |
| rs6275 | 48% (G) | |||||
| Israeli (n = 227) | Dose | ANKK1 | rs7118900 | 18% (A) | A allele carriers required lower doses | [67] |
| BDNF | rs10835210 | 44% (A) | C/C homozygotes required higher doses | |||
| rs1491850 | 43% (C) | C/C homozygotes required lower doses | ||||
| NTRK2 | rs2289658 | 4% (C) | C allele carriers required higher doses | |||
| rs4358872 | 45% (T) | Minor allele homozygotes | ||||
| rs1948308 | 44% (G) | required lower doses | ||||
| rs2378676 | 44% (A) | |||||
| European (n = 244) | Plasma concentration | POR | *28 | 30% (T) | *28/*28 genotype decreased (R)-methadone | [36] |
| European (n = 85) | Dose | KCNJ6 | rs2070995 | 20% (T) | A/A genotype required higher doses | [66] |
| Han Chinese (n = 257) | Dose | OPRD1 | rs529520 | 16% (T) | G/T heterozygotes required higher doses | [42] |
| European-Australian (n = 119) | Plasma concentration | OPRM1 | rs1799971 (A118G) | 16% (G) | G allele with ABCB1 AGTTT haplotype decreased (R)-methadone | [68] |
| African-American (n = 383) | Dose | OPRM1 | rs73568641 | 10% (C) | C allele increased dose | [69] |
| Taiwanese (n = 360) | Plasma concentration | Intergenic | rs17180299 | 3% (G) | G allele increased (R)-methadone | [70] |
| SPON1 GSG1L | 7 haplotypes | Haplotypes associated with (S)-methadone levels |
a
Estimates from 1000 Genomes Project
MAF Predicted minor allele frequency in study ethnicity