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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Mol Cancer Ther. 2018 Feb 14;17(3):698–709. doi: 10.1158/1535-7163.MCT-17-0552

Figure 1.

Figure 1

Time course of MET kinase PD biomarker response (pY1234/1235MET/MET reduction) to single-dose [A] ARQ197, [B] EMD1214063, [C] XL184, and [D] XL880 at increasing dose levels in the SNU-5 xenograft model. The x-axis indicates time after drug administration and is split for resolution. The log-scale y-axis indicates the mean PD biomarker value in each treated group relative to the all-vehicle mean (the 90% inhibition threshold is indicated by the dotted line). Error bars represent SD (n = 3 animals per group).