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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Mol Cancer Ther. 2017 Dec 27;17(3):686–697. doi: 10.1158/1535-7163.MCT-17-0981

Figure 3.

Figure 3

Metastasis and survival of mice pre-treated with HDL NPs prior to tumor cell administration. A, Time-line of C57Bl/6 metastatic lung colonization assay of mice treated with HDL NP (100 μl, 1 μM) or PBS (control) and inoculated with 1 × 105 B16F10 cells. B, Lung colonization 2-weeks after tumor inoculation. Surface metastases appear as darkly pigmented lesions. C, H&E staining of lungs of mice from B. D, Quantification of the number of surface metastases in B. E, Survival curve of PBS and HDL NP pre-treated mice after inoculation with B16F10 cells showing increased survival after HDL NP treatment (n=15 per group). *P = 0.0183 by Log-rank test. P values: *P < 0.05 by two-tailed T test.