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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2018 Feb 14;101(2):479–489. doi: 10.1016/j.ijrobp.2018.02.009

Figure 4.

Figure 4

Comparison of dose distributions with interplay effects at individual CT slice level illustrates that plans using large-spot machine (a) delivered higher dose to nearby healthy organs than the plan using (b) small-spot machine. There was statistically significant difference in (c) total lung V5Gy[RBE], (d) esophagus Dmean, (e) heart D33%, and (f) heart Dmean, illustrating plans using small-spot machine protected the lung, esophagus and heart better than large-spot machine. Averaged values from all 5 runs are shown. (c~f) Error bars indicate the minimum and maximum values among 5 runs. P values were calculated by Wilcoxon signed-rank testing. Abbreviations: RBE = relative biological effectiveness.