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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Mol Cancer Ther. 2017 Dec 13;17(3):661–670. doi: 10.1158/1535-7163.MCT-17-0851

Figure 5. Schematic presentation of the combination therapy with NIR-PIT and NIR-release.

Figure 5

(A) Pan-IR700 is saturated on antigen-positive cells in the immediate perivascular space. 1st NIR light induces a profound perivascular cell death leading to the massive leakage of additional CyEt-Pan-Duo into the tumor bed with greater permeability and penetration. There, CyEt-Pan-Duo binds homogeneously to the surviving fraction of cancer cells. 2nd NIR-light can effectively release duocarmycin from CyEt-Pan-Duo. (B) CyEt-Pan-Duo-only results in saturation of antigen-positive cells in the immediate perivascular space reducing the concentration and dispersion of duocarmycin.