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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Bioorg Med Chem. 2018 Feb 2;26(9):2251–2261. doi: 10.1016/j.bmc.2018.01.024

Scheme 5.

Scheme 5

Reagents and conditions: (a) (1R/S,4R/S)-4-(methoxycarbonyl)cyclohexane-1-carboxylic acid or (1R,4R)-4-(methoxycarbonyl)cyclohexane-1-carboxylic acid or (1R,2S)-2-(methoxycarbonyl)cyclohexane-1-carboxylic acid, EDCI, DMAP, Et3N, DCM/DMF (3:1, v/v), r.t., 16 h.