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Highly active thiazole antigfungal compounds synthesized and evaluated by Khalil et al.22
| Cmpd |
|
H. capsulatum |
C. neoformans (H99 strain) |
|
|---|---|---|---|---|
|
| ||||
| R1 | R2 | IC50 (µM) | IC50 (µM) | |
| 41F5 |
|
|
0.4 | 0.4 |
| A |
|
|
0.4 | > 10 |
| B |
|
|
1.6 | 1.3 |
| C |
|
|
0.7 | > 10 |
