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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Bioorg Med Chem. 2018 Feb 2;26(9):2251–2261. doi: 10.1016/j.bmc.2018.01.024

Table 4.

Activity of 41F5-derived antifungals with monocyclic ring systems or an acyclic ethyl group at the 5-position

graphic file with name nihms954422u5.jpg H. capsulatum C. neoformans
(H99 strain)		 P388D1 SI
(Hc)		 SI
(Cn)
Comp R1 R2 IC50 (µM)
[±SD]		 MIC
(µM)		 IC50 (µM)
[±SD]		 MIC
(µM)		 IC50 (µM)
[±SD]
C graphic file with name nihms954422t51.jpg graphic file with name nihms954422t52.jpg 0.80 [±0.04] 1.25 > 20 > 40 > 40 > 50 nd
B graphic file with name nihms954422t53.jpg graphic file with name nihms954422t54.jpg 1.06 [±0.06] 2.50 1.36 [±0.10] 2.50 > 40 > 38 > 29
25a graphic file with name nihms954422t55.jpg graphic file with name nihms954422t56.jpg > 20 > 40 > 20 > 40 nd nd nd
25b graphic file with name nihms954422t57.jpg graphic file with name nihms954422t58.jpg 0.76 [±0.05] 1.25 > 20 > 40 > 40 > 53 nd
29a graphic file with name nihms954422t59.jpg graphic file with name nihms954422t60.jpg 8.09 [±0.70] 20.00 > 20 > 40 > 40 > 5 nd
29b graphic file with name nihms954422t61.jpg graphic file with name nihms954422t62.jpg 18.30 [±1.06] 40.00 7.17 [±0.84] 20.00 > 40 > 2 > 6
30a C2H5 graphic file with name nihms954422t63.jpg > 20 > 40 > 20 > 40 nd nd nd
30b C2H5 graphic file with name nihms954422t64.jpg > 20 > 40 > 20 > 40 nd nd nd
31 graphic file with name nihms954422t65.jpg graphic file with name nihms954422t66.jpg > 20 > 40 > 20 > 40 nd nd nd
32a graphic file with name nihms954422t67.jpg graphic file with name nihms954422t68.jpg 7.67 [±0.25] 20.00 > 20 > 40 > 40 > 5 nd
32b graphic file with name nihms954422t69.jpg graphic file with name nihms954422t70.jpg > 20 > 40 > 20 > 40 nd nd nd

SD: Standard deviation; SI: Selectivity index, nd: not determined