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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Bioorg Med Chem. 2018 Feb 2;26(9):2251–2261. doi: 10.1016/j.bmc.2018.01.024

Table 5.

Activity of antifungals with oxazole- and imidazole core structures

graphic file with name nihms954422u6.jpg H. capsulatum C. neoformans
(H99 strain)		 P388D1 SI
(Hc)		 SI
(Cn)
Cmpd X Y R1 R2 IC50 (µM)
[±SD]		 MIC
(µM)		 IC50
(µM)		 MIC
(µM)		 IC50
(µM)
38a CH O graphic file with name nihms954422t71.jpg graphic file with name nihms954422t72.jpg > 20 > 40 > 20 > 40 nd nd nd
38b CH O graphic file with name nihms954422t73.jpg graphic file with name nihms954422t74.jpg > 20 > 40 > 20 > 40 nd nd nd
40 CH NH graphic file with name nihms954422t75.jpg graphic file with name nihms954422t76.jpg 8.11 [±0.33] 20.00 > 20 > 40 > 40 > 5 > 2

SD: Standard deviation; SI: Selectivity index, nd: not determined