Table 1.
Patient characteristic before and after matching
| Characteristics | Before matching | After matching | ||||||
|---|---|---|---|---|---|---|---|---|
| All | RA/depression | RA only | Standardized difference | All | RA/depression | RA only | Standardized difference | |
| N = 7311 | N = 473 | N = 6838 | N = 2270 | N = 454 | N = 1816 | |||
| Gender | ||||||||
| Female | 5391 (73.74%) | 375 (79.28%) | 5016 (73.35%) | 0.14121* | 1799 (79.25%) | 358 (78.85%) | 1441 (79.35%) | − 0.01219 |
| Male | 1920 (26.26%) | 98 (20.72%) | 1822 (26.65%) | 471 (20.75%) | 96 (21.15%) | 375 (20.65%) | ||
| Age at index-date | ||||||||
| Mean (Sd) | 51.93 (10.94) | 52.55 (10.72) | 51.89 (10.95) | 0.06128 | 52.64 (10.91) | 52.41 (10.68) | 52.70 (10.97) | − 0.02664 |
| Min–Max | [18.0; 75.0] | [21.0; 75.0] | [18.0; 75.0] | [18.0; 75.0] | [21.0; 75.0] | [18.0; 75.0] | ||
| Median | 53 | 53 | 53 | 54 | 53 | 54 | ||
| Q1–Q3 | [44.0; 60.0] | [46.0; 60.0] | [44.0; 60.0] | [45.0; 60.0] | [46.0; 60.0] | [45.0; 60.0] | ||
| Calendar year of index date | ||||||||
| 2010 | 1471 (20.12%) | 59 (12.47%) | 1412 (20.65%) | 0.36993* | 277 (12.20%) | 59 (13.00%) | 218 (12.00%) | 0.04186 |
| 2011 | 716 (9.79%) | 46 (9.73%) | 670 (9.80%) | 232 (10.22%) | 46 (10.13%) | 186 (10.24%) | ||
| 2012 | 728 (9.96%) | 56 (11.84%) | 672 (9.83%) | 268 (11.81%) | 53 (11.67%) | 215 (11.84%) | ||
| 2013 | 2739 (37.46%) | 147 (31.08%) | 2592 (37.91%) | 720 (31.72%) | 147 (32.38%) | 573 (31.55%) | ||
| 2014 | 1001 (13.69%) | 82 (17.34%) | 919 (13.44%) | 403 (17.75%) | 78 (17.18%) | 325 (17.90%) | ||
| 2015 | 656 (8.97%) | 83 (17.55%) | 573 (8.38%) | 370 (16.30%) | 71 (15.64%) | 299 (16.46%) | ||
| Follow-up duration in months | ||||||||
| Mean (Sd) | 31.08 (19.23) | 27.37 (18.97) | 31.34 (19.22) | 0.08418 | 27.69 (18.35) | 28.07 (18.92) | 27.59 (18.21) | 0.01201 |
| Min–Max | [1.0; 71.0] | [1.0; 71.0] | [1.0; 68.0] | [1.0; 71.0] | [1.0; 71.0] | [1.0; 68.0] | ||
| Median | 29 | 27 | 29 | 28 | 27 | 28 | ||
| Q1–Q3 | [17.0; 42.0] | [11.0; 37.0] | [17.0; 43.0] | [13.0; 38.0] | [12.0; 38.0] | [13.0; 39.0] | ||
| Charlson comorbidity index (CCI) | ||||||||
| Mean (Sd) | 2.08 (1.77) | 2.25 (2.42) | 2.07 (1.71) | − 0.20821* | 2.12 (1.84) | 2.14 (2.28) | 2.12 (1.71) | 0.02562 |
| Min–Max | [0.0; 19.0] | [0.0; 16.0] | [1.0; 19.0] | [0.0; 15.0] | [0.0; 12.0] | [1.0; 15.0] | ||
| Median | 1 | 2 | 1 | 1 | 2 | 1 | ||
| Q1–Q3 | [1.0; 3.0] | [1.0; 3.0] | [1.0; 3.0] | [1.0; 3.0] | [0.0; 3.0] | [1.0; 3.0] | ||
| Renal failure | ||||||||
| Yes | 97 (1.33%) | 12 (2.54%) | 85 (1.24%) | 0.09513 | 41 (1.81%) | 8 (1.76%) | 33 (1.82%) | − 0.00415 |
| No | 7214 (98.67%) | 461 (97.46%) | 6753 (98.76%) | 2229 (98.19%) | 446 (98.24%) | 1783 (98.18%) | ||
| Interstitial pneumonia | ||||||||
| Yes | 167 (2.28%) | 10 (2.11%) | 157 (2.30%) | − 0.01238 | 48 (2.11%) | 10 (2.20%) | 38 (2.09%) | 0.0076 |
| No | 7144 (97.72%) | 463 (97.89%) | 6681 (97.70%) | 2222 (97.89%) | 444 (97.80%) | 1778 (97.91%) | ||
| COPD | ||||||||
| Yes | 665 (9.10%) | 73 (15.43%) | 592 (8.66%) | 0.20931* | 315 (13.88%) | 59 (13.00%) | 256 (14.10%) | − 0.03219 |
| No | 6646 (90.90%) | 400 (84.57%) | 6246 (91.34%) | 1955 (86.12%) | 395 (87.00%) | 1560 (85.90%) | ||
| Peptic ulcer | ||||||||
| Yes | 14 (0.19%) | 1 (0.21%) | 13 (0.19%) | 0.00476 | 3 (0.13%) | 1 (0.22%) | 2 (0.11%) | 0.02712 |
| No | 7297 (99.81%) | 472 (99.79%) | 6825 (99.81%) | 2267 (99.87%) | 453 (99.78%) | 1814 (99.89%) | ||
| Chronic liver disease | ||||||||
| Yes | 68 (0.93%) | 4 (0.85%) | 64 (0.94%) | − 0.00961 | 19 (0.84%) | 4 (0.88%) | 15 (0.83%) | 0.00599 |
| No | 7243 (99.07%) | 469 (99.15%) | 6774 (99.06%) | 2251 (99.16%) | 450 (99.12%) | 1801 (99.17%) | ||
| Osteoporosis | ||||||||
| Yes | 2000 (27.36%) | 145 (30.66%) | 1855 (27.13%) | 0.07789 | 656 (28.90%) | 133 (29.30%) | 523 (28.80%) | 0.01092 |
| No | 5311 (72.64%) | 328 (69.34%) | 4983 (72.87%) | 1614 (71.10%) | 321 (70.70%) | 1293 (71.20%) | ||
| Diabetes | ||||||||
| Yes | 1965 (26.88%) | 122 (25.79%) | 1843 (26.95%) | 0.03853 | 540 (23.79%) | 114 (25.11%) | 426 (23.46%) | 0.03853 |
| No | 5346 (73.12%) | 351 (74.21%) | 4995 (73.05%) | 1730 (76.21%) | 340 (74.89%) | 1390 (76.54%) | ||
*Absolute standardized differences > 10%