Table 2.

Binding affinity (pKi) of 5-HT_1B, 5-HT_1D and 5-HT_1F to several compounds used as or developed to be antimigraine treatments

Compound	5-HT1B	5-HT1D	5-HT1F
Dihydroergotamine	9.2	9.4	6.6
Naratriptan	8.5	8.6	8.4
Rizatriptan	8	8.4	6.6
Sumatriptan	8	8.3	7.6
Zolmitriptan	8.3	9	7.6
LY334370	6.9	6.9	8.8
LY302148	7.3	7.7	8.6
LY306258	5.8	6.1	8.0
LY334864	6.3	6.2	8.2

The pKi value is for the human 5-HT_1B, 5-HT_1D and 5-HT_1F receptors. For pKi values, affinity increases as the value increases. Adapted from [28, 29]