Table 3.
Binding affinity of lasmiditan at human 5-HT receptors
| 5-HT1A | 5-HT1B | 5-HT1D | 5-HT1F | 5-HT2A | 5-HT2B | 5-HT2C | 5-HT6 | 5-HT7 |
|---|---|---|---|---|---|---|---|---|
| 1053 (± 134) | 1043 (± 124) | 1357 (± 156) | 2.21 (± 0.22) | > 5 μM | > 2 μM | > 3 μM | > 4 μM | > 3 μM |
Values are expressed as Ki in nanomolars (unless otherwise indicated) and represent the average ± SEM of more than five separate experiments. “>” indicates that less than 50% inhibition of binding was obtained at the specified concentration. For Ki values, affinity increases as the value decreases. Adapted from [49]