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. 2017 Jul 1;3(1):87–96. doi: 10.1016/j.bioactmat.2017.06.003

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — The fabrication process of various multilayered composite nanoparticles. a) Controlled formation of the nanogel core, silica shell-nanogel core NPs (GS), pH-responsive poly-(acrylic acid) (PAA)-silica-nanogel NPs (GSP), and hydroxyapatite (HA) coated PAA-silica-nanogel NPs (GSPH). b) Magnetic-responsive release produced by magnetic silica-nanogel NPs under high-frequency alternating magnetic fields (HFMF). c) pH-responsive release of PAA-silica-nanogel NPs. d) In-vivo translation of multilayered composite nanoparticles toward periosteum-mimetic biomaterials for bone repair.