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. 2018 May 4;8:7035. doi: 10.1038/s41598-018-24722-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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mEPSC frequency is significantly increased in CA3 pyramidal cells during OGD. (A) Representative traces from a control C57BL/6 mouse recorded at baseline, during OGD and during reoxygenation (reox) demonstrating an increase in mEPSC frequency during OGD. (B) Averaged data demonstrating that mEPSC frequency is significantly increased during OGD and returns to baseline levels during reox as a percent of baseline (n = 9 cells, 7 animals; baseline, Bsl: 0.5 ± 0.1 Hz; OGD: 0.72 ± 0.14 Hz; reox: 0.45 ± 0.06 Hz). *p < 0.05, K-W ANOVA. Data presented as percent mean ± SEM. (C) Representative inter-event cumulative frequency histogram demonstrating a reduction in the inter-event interval during OGD. (D) Representative amplitude cumulative histogram demonstrating no change in mEPSC amplitude during OGD (baseline, Bsl: 14.2 ± 1.58 pA; OGD: 16.14 ± 1.54 pA; reox: 15.8 ± 1.91 pA). Inset showing averaged data for mEPSC amplitude at baseline, during OGD and during reox. Data presented as percent mean ± SEM. Baseline, solid line; OGD, dashed line; reox, dotted line.