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. 2018 May 4;8:7061. doi: 10.1038/s41598-018-25321-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the timeline in the severe asthma with fungal sensitization model (SAFS). Age and gender-matched mice are administered antigen from Aspergillus fumigatus extract via subcutaneous (SQ) and intraperitoneal (IP) injections. Following a 2 week rest period, antigen is administered via intranasal (IN) route once a week for three weeks. Sensitized mice are then exposed to conidia liberated from live fungal cultures for 10 minutes at a time two weeks apart via inhalation (IH). Samples were harvested at days 7 and 35 after the second fungal challenge.