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. 2018 May 4;8:7061. doi: 10.1038/s41598-018-25321-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RELM-β promotes peribronchovascular inflammation. Peribronchovascular inflammation was highest at early time points and gradually decreased over time in both genotypes compared to naïve controls (A), and Retnlb^−/− mice had less tissue inflammation compared to WT (B). Tissue eosinophils were lower in KO mice compared to WT (C). Scale bar = 200 µm and applicable to all photo micrographs. Naïve mice in each genotype were scored 0 and did not contain tissue eosinophils. Data are represented as the mean and SD of n = 4–7 mice/group in one representative study of two independent studies. Data at each time point were compared by two-way ANOVA with Dunnett’s and Sidak’s multiple comparisons test to their naïve controls († and Δ), and between genotypes (*) respectively. One, two, and three symbols represent P < 0.05, P < 0.01, and P < 0.001 correspondingly. HPF – high power field.