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. 2018 May 4;8:7061. doi: 10.1038/s41598-018-25321-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RELM-β inhibits goblet cell (GC) differentiation and Muc gene expression. Goblet cells were not observed in the naïve (N) controls of either genotype but were abundant in the airway lining after allergen exposure (A). While GCs consisted of approximately 40% of the epithelial lining in both genotypes at the early time point, these cells reduced over time to only about 20% at the late time point (B). More GCs were present in the airways of Retnlb^−/− mice at Day 7 (B), corresponding with greater expression of mucus genes, Muc5ac and Muc5b (C). Scale bar = 200 µm applicable to all photo micrographs. Data are represented as the mean and SEM of n = 4–7 mice/group in one representative study of two independent studies. Data at each time point were compared by two-way ANOVA with Dunnett’s and Sidak’s multiple comparisons test to their naïve controls († and Δ), and between genotypes (*) respectively. Three symbols represent P < 0.05 and P < 0.001 correspondingly.