Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 4;8:7039. doi: 10.1038/s41598-018-25468-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Infertility in IP6K1 deleted males was caused by scarce and malformed sperm. (a) None of IP6K1 KO male mice (n = 7) impregnate wild type females. By contrast, IP6K2 KO males (n = 6), IP6K3 KO males (n = 6) and IP6K2/IP6K3 double KO males (n = 6) are able to produce progeny. (b) IP6K1 KO male mice (n = 7) were set to mate with wild type female mice, mating plugs were found in six of 7 wild type female mice. Six pairs of WT male and female mice were set as controls. (c,d) Sperm cells were isolated from epididymides. (c) Bright-field microscopy shows severed sperm tails (arrows) but no motile sperm cells in IP6K1 KOs. Scale bar 50 μm. (d) Immunostaining of acetyl-α-tubulin for sperm tails. Nuclei were stained by DAPI. Severed sperm tails (arrow) and sperm heads coiled by sperm tails (arrowhead) were seen in the IP6K1 mutants. Scale bar 20 μm.