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. 2018 May 4;8:7047. doi: 10.1038/s41598-018-25526-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of RA on the Src-YAP-IL6 axis in triple-negative MDA-MB-231 and MDA-MB-468 breast cancer cells. MDA-MB-231 and MDA-MB-468 breast cancer cells were incubated for two days in the absence (-RA) or presence (+RA) of retinoic acid (5 μM). (A) Western blots of MDA-MB-231 cells show the increase in tyrosine phosphorylation of Src and YAP determined in nuclear extracts and the increase of IL-6 expression assessed in cell lysates and the culture medium. The bar graphs show quantification of data from three independent experiments. β-Actin and Ponceau staining were used as loading controls. (B) Western blots of MDA-MB-468 breast cancer cells show the decrease in tyrosine phosphorylation of Src and YAP determined in nuclear extracts and the decrease of IL-6 expression assessed in cell lysates. The bar graphs show quantification of data from three independent experiments. β-Actin was used as loading control. Full-length figures of the cropped blots are in Supplementary Figures S1–S4.