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. 2018 May 4;8:7055. doi: 10.1038/s41598-018-25489-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MIR-143HG promoter activity is modulated by hypoxia. (a) Hypoxic treatment increases the promoter activity of HIF1a. (b) Western blot analysis of HIF-1a protein level in HCMa after hypoxic treatments (c) Mutagenesis analyses of MIR143HG promoter demonstrate the essential roles of hypoxia response elements in hypoxia induced transcriptional activation for MIR143HG. The mutated HRE sites are indicated by underlined gray fonts. No change in the NPR3 promoter activity was observed after hypoxia treatment. Data are presented as mean ± SD, n = 3, Student’s t test, *p < 0.05.