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. 2018 May 4;8:7055. doi: 10.1038/s41598-018-25489-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential promoter activities of MIR143HG and MIR100HG in the presence of exogenous miR-100 or miR-143 in HCMa cells. (a) Promoter activities of MIR143HG were enhanced and inhibited in the presence of exogenous miR-143 and miR-100 respectively. (b) Promoter activity of MIR100HG was attenuated in the presence of miR-143 mimics. (c) Mutagenesis analyses of MIR143HG promoter showing that miR-143 and miR-100 failed to interact with promoter constructs containing the mutated transcriptional response elements (MTRE) representing the respective microRNA binding sites. Inset in (c) depicts the relative locations of the TREs tested in this study. Data are presented as mean ± SD, n = 3, Student’s t test, *p < 0.05. n.s, non-significance, p > 0.05.