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. 2018 May 4;8:7062. doi: 10.1038/s41598-018-25571-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HMPC resistance-associated mutations in MgrA map to the DNA-binding domain. The MgrA dimer (PDB: 2BV6) is shown with the two equivalent subunits colored light blue and white/grey. Missense variants at Val55, Pro71, and Arg84 (shown in red) are all found in the winged-helix DNA-binding domain (left, bottom half), including in the DNA recognition helix. Image created in PyMOL with Flaticon.