Table 3.
The correlations between nuclear HuR expression and the clinical features of GC patients. P value < 0.05 was indicated in bold.
Variable | N | Nuclear HuR expression | P value | |||
---|---|---|---|---|---|---|
HuR-high | % | HuR-low | % | |||
Sex | 251 | |||||
Male | 178 | 116 | 65.2 | 62 | 34.8 | 0.613 |
Female | 73 | 50 | 68.5 | 23 | 31.5 | |
Age | ||||||
<60 | 80 | 49 | 61.2 | 31 | 38.8 | 0.263 |
≥60 | 171 | 117 | 68.4 | 54 | 31.6 | |
Depth of invasion | ||||||
T1-T3 | 82 | 47 | 57.3 | 35 | 42.7 | 0.040 |
T4 | 169 | 119 | 70.4 | 50 | 29.6 | |
Lymph node metastasis | ||||||
Absent (N0) | 104 | 63 | 60.6 | 41 | 39.4 | 0.118 |
Present (N1-N3) | 147 | 103 | 70.1 | 44 | 29.9 | |
Distant metastasis | ||||||
M0 | 226 | 146 | 64.6 | 80 | 35.4 | 0.123 |
M1 | 25 | 20 | 80.0 | 5 | 20 | |
TNM Stage | ||||||
1 + 2 | 116 | 67 | 57.8 | 49 | 42.2 | 0.009 |
3 + 4 | 135 | 99 | 73.3 | 36 | 26.7 | |
Tumor size (cm) | ||||||
>5 | 93 | 70 | 75.3 | 23 | 24.7 | 0.019 |
≤5 | 158 | 96 | 60.8 | 62 | 39.2 | |
Differentiation status | ||||||
Well/Moderate | 147 | 95 | 64.6 | 52 | 35.4 | 0.548 |
Poor/Undifferentiated | 104 | 71 | 68.3 | 33 | 31.7 | |
TTP-expression | ||||||
TTP-high | 101 | 58 | 57.4 | 43 | 42.6 | 0.017 |
TTP-low | 150 | 108 | 72.0 | 42 | 28.0 | |
Cytoplasmic HuR | ||||||
Positive | 81 | 58 | 71.6 | 23 | 28.4 | 0.206 |
Negative | 170 | 108 | 63.5 | 62 | 36.5 |