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. 2018 May 4;8:7044. doi: 10.1038/s41598-018-25395-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of gene expression profiles of clonal OA cartilage-derived MSCs, PHCs and BM-MSCs. (A) Relative mRNA expression mesenchymal transcription factor PRX1, (B) type X collagen (COL10A1), (C) RUNX2, (D) chondrogenesis transcription factor SOX9, (E) cartilage matrix protein matrilin-3, (F) cartilage surface lubricating protein PRG4, (G) Indian hedgehog (IHH), (H) hedgehog interacting protein (HHIP), (I) and stromal marker COL1A1, in primary human chondrocytes (PHCs), bone marrow mesenchymal stem cells (BM-MSCs), OA-MSC2 and OA-MSC18. n ≥ 3. *p ≤ 0.05, relative to the chondrocyte group. ^#p ≤ 0.05. Data are represented as mean ± SD.