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. 2018 May 4;8:7044. doi: 10.1038/s41598-018-25395-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of RUNX2 and NOTCH1 are required to attenuate type X collagen expression in clonal OA cartilage-derived MSCs. (A–C) mRNA expression of COL10A1, ADAMTS5 and MMP-13 following transient siRNA-based knockdown of RUNX2 and/or NOTCH1 in OA-MSCL2 and (D–F) in OA-MSCL18 using. n ≥ 3. **p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.005 relative to scrambled siRNA control transfected group. Data are represented as mean ± SD.