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. 2018 May 4;8:7059. doi: 10.1038/s41598-018-25384-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dry eye disease promotes loss of Foxp3 expression by Tregs following corneal transplantation. Foxp3-GFP-CreXR26-RFP transgenic mice were used to trace Foxp3 expression after transplantation. Healthy corneal grafts were transplanted onto transgenic naïve control hosts or dry eye (DED) hosts. Draining lymph nodes were harvested 2 weeks post-transplantation. Single cell suspensions were analyzed by flow cytometry. (A) Representative flow cytometry plots and (B) statistical analysis of flow cytometry data showing frequencies of exFoxp3 cells in Foxp3-GFPXR26-RFP control and DED hosts (n = 6/group, ***p < 0.001). (C) Representative flow cytometry plots and (D, E) statistical analyses of flow cytometry data showing frequencies of exFoxp3 cells that express IFNγ (***p < 0.001) and IL-17 (**p < 0.01) in Foxp3-GFPXR26-RFP control and DED hosts (n = 6/group). Data is presented as mean ± SEM (error bar).