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a) Cranial defects with 14 mm in diameter were created in the parietal bones by a hand powered trephine. Initial defect before implantation (top) and 12 weeks after implantation of nanoparticulate mineralized collagen/GAG scaffolds (bottom) cranial defects are shown. b) Representative three-dimensional reconstructions of the CT scans of two kinds of scaffold with cross sections are shown [133].
