Table 2.

Aggressive non-alcoholic steatohepatitis histologic findings

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6
Specimen	Autopsy	Explant	Explant	Autopsy	Needle biopsy	Needle biopsy
Gross findings	Massive hepatomegaly with focal infarcts (6680 g)	Micronodular cirrhosis (1825 g)	Early micronodular cirrhosis (1491 g)	Massive hepatomegaly with severe fatty change (5600 g)	Not available	Not available
Fibrosis stagea	Stage 3	Stage 4	Stage 4	Stage 3	Stage 3–4	Stage 3
Total macrovesicular steatosis (large and small droplet; %)	80%	10%	40%	40%	40%	80%
Severe centrizonal scarring	Yes	Yes	Yes	Yes	Yes	Yes
Location of steatosis	Panacinar	Azonal	Panacinar	Azonal	Panacinar	Panacinar
Ballooned hepatocytes	Prominent	Prominent	Prominent	Prominent	Prominent	Prominent
Mallory–Denk bodies	Many	Many	Many	Many	Many	Many
Ductular reaction	Yes	Yes	Yes	Yes	No	Yes
Cholestasis	No	Yes	Yes	Yes	No	No
Perivenular sclerosis/occlusion	No/No	Yes/Yes	Yes/Yes	Yes/No	Yes/Yes	Yes/Yes
Centrizonal arteries	No	Yes	Yes	Yes	Yes	Yes
Trichrome staining pattern	Bridging fibrosis	Two-tone staining pattern	Two-tone staining pattern	Bridging fibrosis	Two-tone staining pattern	Two-tone staining pattern
Elastic stain results (Elastic can Gieson and/or orcein stains)	Not available	Lack of elastic fibers in centrizonal scars	Lack of elastic fibers in centrizonal scars	Not available	Lack of elastic fibers in centrizonal scars	Not available

^aAccording to the Non-alcoholic Steatohepatitis Clinical Research Network staging methodology.²²