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. 2015 Nov 18;2:34–53. doi: 10.1016/j.conctc.2015.10.002

Table 2.

Selected Powers and Sample Sizes at One-sided α = 0.025 for the Combination Test at the Specified DRDS Design Parameter Values and the Hypothetical Distributions of a HDRS17 Subscale Score under Treatment and Placebo as given in Table 1 (DRDS Design Parameter Values: r1 = 2, r2 = 1, c = 2.50, γ = 0.42), Δ = α11 + α22|C.

μ1T μ1P Δ1 σ1 ρP ρT Δ2|C σ2|C Δ 1 − β N1 n1T n2T
3.30 3.00 0.30 2.42 0.80 0.20 1.43 3.18 0.42 80% 960 320 134
85% 1098 366 154
90% 1287 429 180
0.80 0.50 0.88 3.28 0.38 80% 1338 446 187
85% 1587 529 222
90% 1893 631 265