Table 1.
Grading of neuroendocrine neoplasias of the cervix
| Classification/Grade | Mitotic Indexa | Ki-67 Indexb |
|---|---|---|
| Well-differentiated NEN | ||
| NET G1 | < 2/10 | ≤ 2 |
| NET G2 | 2–20 | 3–20 |
| NET G3c | > 20 | > 20 |
| Poorly differentiated NEN | ||
| NEC G3 | > 20 | > 20 |
| Small cell carcinoma | ||
| Large cell carcinoma | ||
According to Kim et al. [2]. NEN neuroendocrine neoplasia, NET neuroendocrine tumor, NEC neuroendocrine carcinoma
aMitotic index: based on the evaluation of mitoses in 50 high-power fields (HPF; 0.2 mm2 each) in areas of higher density; expressed as mitoses per 10 high-power fields (mitoses/2 mm2)
bKi-67 proliferation index: based on the evaluation of ≥500 tumor cells in areas of higher nuclear labeling (so-called hotspots)
cNET G3 is defined as NET with Ki-67 proliferation index/mitotic index > 20 and without morphological features of small cell NEC or large cell NEC