Table 1.

Analyses of HMA combinations with AraC on BCP-ALL cells

		Drug combination effect
		AZA + AraC	AZA + AraC (24 h)	AraC + AZA (24 h)	DEC + AraC	DEC + AraC (24 h)	AraC + DEC (24 h)
SEM	Metabolism	0.095	0.045	0.004	0.022	− 0.039	− 0.077
	Proliferation	0.064	0.006	0.001	0.017	− 0.048	0.041
RS4;11	Metabolism	0.076	− 0.055	− 0.018	0.128	− 0.032	− 0.043
	Proliferation	0.016	0.044	− 0.003	0.000	0.025	0.076

Drug combination effect: difference between the observed and the expected inhibition (E) of combined treatment. E is calculated as follows: E = (A + B) − (A*B); A is inhibition effect of drug A; B inhibition effect of drug B values > 0: synergistic, values < 0: antagonistic