Table 2.

Analyses of HMA combinations with Doxo on BCP-ALL cells

		Drug combination effect
		AZA + Doxo	AZA + Doxo (24 h)	Doxo + AZA (24 h)	DEC + Doxo	DEC + Doxo (24 h)	Doxo + DEC (24 h)
SEM	Metabolism	− 0.071	− 0.230	0.006	− 0.046	− 0.117	− 0.021
	Proliferation	− 0.002	− 0.192	0.015	− 0.014	− 0.094	− 0.042
RS4;11	Metabolism	− 0.009	− 0.118	0.086	− 0.007	− 0.071	0.044
	Proliferation	− 0.022	− 0.227	0.016	− 0.028	− 0.301	0.011

Drug combination effect: difference between the observed and the expected inhibition (E) of combined treatment. E is calculated as follows: E = (A + B) − (A*B); A is inhibition effect of drug A; B inhibition effect of drug B values > 0: synergistic, values < 0: antagonistic