Table 1.

Summary of papers identified

Author	Study design	Title of article	Population(Location) and study setting	Year of enrolment	Original number enrolled and number followed up	Control and intervention	Primary outcome and tools used	Age of the children when outcome measured
1. Zhou et al. 2006 [11]	RCT	Effect of iron supplementation during pregnancy on the intelligent quotient and behaviour of children at 4 years of age: long term follow up of a randomized controlled trial	AMBIT Women’s and children’s hospital, Adelaide, Australia Urban setting	Original trial 1997–1999 May 2002 Jan 2004	430 pregnant women enrolled IQ assessed I -153 C -149 Behaviour assessed I -151 C -149	I = from 20wks of gestation to delivery birth 20 mg of iron C = placebo	Stanford Binet Intelligence Scale (SBIS) used to assess IQ and Strengths and Difficulties Questionnaire (SDQ) used to assess behaviour	4 years
2. Parsons et al. 2007 [20]	RCT	Effect of iron supplementation during pregnancy on the behaviour of children at early school age: long term follow up of a randomised control trial	Ditto	April to Nov 2006	430 pregnant women enrolled Behaviour assessed 264 I = 132 C - 132	Ditto	Strength and Difficulties Questionnaire (SDQ) used to assess Behaviour	6–8 years
3. Li et al. 2009 [27]	Follow up of RCT	Effect of maternal multi-micronutrient supplementation on the mental development infants in rural Western China	China Rural setting of Shaanxi Province of Western China	Original research Aug 2002 to Jan 2006 Followed up from Jan 2004- Dec 2004	5828 women enrolled for the original trial and there were 4604 live births. For this component 1305 subset of infants assessed I – 471&396 C - 438	Once pregnancy diagnosed but before 28 weeks of gestation I = FA 400+ Fe60 C = FA 400	Bayle’s Scale of Infant development (BSID) used to assessed Mental & psychomotor development	3, 6 & 12 month of age
4. Chang et al. 2013 [26]		Effect of iron deficiency anaemia in pregnancy on child mental development in rural China	Ditto	2004–2006	5828 women enrolled for the original trial and there were 4604 live births. For this component 1286 subset of children assessed C = 468 I-423 & 395	I = FA 400 + Fe60 C = FA 400	Bayley’s Scale of Infant development (BSID) used to assessed Mental Development Index and Psychomotor Development Index	3, 6, 12, 18, & 24 months of age
5. Li et al. 2015 [28]	Follow up of RCT	Prenatal micronutrient supplementation is not associated with intellectual development of young school aged children	Ditto	2012–2013	For this component subset of 1744 children were assessed C -604 I -562 & 578	I = FA 400+ Fe60. C = FA 400	WISC-IV (Wechsler intelligence scale for Children Verbal comprehension scale, working memory index, perceptual reasoning, processing speed index	7–9 years
6. Christian et al. 2010 [12]	Follow up of RCT	Prenatal micronutrient supplementation and intellectual and motor function in early school aged children in Nepal	Nepal Rural setting of Southern Sarlahi district.	Original trial done from 1999 to 2001. Follow-up study from June 2007–April 2009	4998 women enrolled for the original and for this component 676 infants were enrolled. C -177. I -103 &178 7218	From 11 weeks of gestation I = Fe60 + FA 60 + Vitamin A. C=Vitamin A	Universal Non Verbal Intelligence Test (UNVIT)	7–9 years of age
7. Angulo-Barroso et al. 2016 [18]	RCT	Iron supplementation in pregnancy or infancy and motor development: a RCT	China Rural setting of Hebei province.	June 2009 to Dec 2011. assessment done from Sep 2010 to Mar 2013	2371 recruited for the original study. I-1185. C- 1186	From enrolment to birth I = Fe300 + FA. C = Placebo + FA	Peabody Development Motor Scale second edition PDMS II). Used to assess gross motor development	9 months of age