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. Author manuscript; available in PMC: 2018 May 5.
Published in final edited form as: Annu Rev Microbiol. 2017 Jun 23;71:179–195. doi: 10.1146/annurev-micro-090816-093325

Figure 3.

Figure 3

The trigger enzyme system of Escherichia coli. The global c-di-GMP pool is partially controlled by the DGC YegE and the PDE YhjH. When the c-di-GMP pool is low, the trigger enzyme and PDE YciR bind the DGC YdaM and its target, the transcription factor MlrA (bold arrows), preventing YdaM activation of MlrA. When the c-di-GMP pool is high, YciR degrades c-di-GMP and releases YdaM and MlrA in the process, leading to YdaM activation of MlrA and further contribution to the global c-di-GMP pool (blue arrow). Adapted from Lindenberg et al. (38).