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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2018 Apr 12;1865(7):959–969. doi: 10.1016/j.bbamcr.2018.04.005

Figure 5. CBP.001 alone or with AraC reduces viable AML cells in the presence of MSC.

Figure 5

(A) THP-1 cells were co-cultured with MSC for 24 hours and then were treated with vehicle, 30 ug/ml CBP.001, 1 uM AraC, or combination of both agents at single agent dose for 48 hours and then adherent AML cells were isolated. Flow cytometry was performed to determine (A) total viable THP1 cells (CD90-/Annexin V-/DAPi-) and (B) % apoptotic cells (CD90-/Annexin V +). For A & B, data represents average of three different replicates. Student t-test comparison of groups compared to control (untreated) determined a significant difference in all treated groups (**, p < 0.01).