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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2018 Apr 12;1865(7):959–969. doi: 10.1016/j.bbamcr.2018.04.005

Figure 7. Model of role of LGALS3 in MSC in the leukemia niche.

Figure 7

LGALS3 positively regulates MYC and AKT while negatively regulating ITGB3. LGALS3 supports AML cell adhesion and survival in the leukemia microenvironment. LGALS3 inhibitor CBP.001 blocks LGALS3 ability to support MSC mediated survival and adhesion of AML cells.