Table 2.

Overlap between mouse Mdq loci and breast cancer risk loci in humans¹

QTL	Lead SNP	P	Effect Sizea	Human locus	Human Syntenic Locationb	Breast Cancer Risk Loci	Nearest BrCa SNP	GWAS P	Distance to Mouseb	iCOGS Pc	Combined GWAS iCOG Pc
Mdq1	rs29972830	9.E-12	0.26	7q32.3	132.73	YESd	rs4593472	3.E-05	2.06	4.E-06	2.E-09
Mdq2	rs32398376	2.E-09	0.21	1q25.3	183.13	NO	rs11249433	7.E-10	61.85
Mdq3	rs13483228	3.E-09	0.21	18q12.1	28.16	YES	rs1436904	1.E-03	3.59	5.E-06	3.E-08
Mdq4	rs33051600	3.E-08	0.2	2q24.3	169.07	YES	rs2016394	1.E-02	3.90	2.E-06	8.E-06
Mdq5	rs30095733	6.E-08	0.17	5q11.2	51.23	YES	rs889312	7.E-20	4.81	3.E-27	1.E-39
Mdq6	rs46013670	8.E-08	0.18	3q21.1	122.88	NO	rs1053338	2.E-02	58.91	2.E-07	9.E-09
Mdq7	rs50444438	1.E-07	0.17	7p15.3	21.90	NO	rs6977610	2.E-04	6.64
Mdq8	rs27176282	1.E-07	0.17	10p12.3	22.21	YES	rs11814448	4.E-05	0.11	3.E-13	6.E-17
Mdq9	rs36588132	1.E-07	0.16	3p22.3	33.06	YES	rs12493607	4.E-02	2.38	7.E-08	1.E-08
Mdq10	rs29830755	2.E-07	0.16	7p15.1	28.64	NO	rs6977610	2.E-04	13.38
Mdq11	rs3696903	4.E-07	0.17	11p15.2	16.42	NO	rs909116	7.E-07	14.48
Mdq12	rs33753649	5.E-07	0.17	22q12.1	25.95	YES	rs132390	1.E-03	3.67	4.E-07	3.E-09
Mdq13	rs30305626	7.E-07	0.15	7q31.2	117.30	NO	rs2048672	6.E-06	13.35
Mdq14	rs27275156	8.E-07	0.15	20p13	4.75	NO	rs6109595	1.E-04	8.11
Mdq15	rs29778211	8.E-07	0.14	12q24.21	114.97	YES	rs1265507	1.E-08	0.54
Mdq16	rs31558147	8.E-07	0.15	4q12	56.08	YES	rs11732323	6.E-05	0.43
Mdq17	rs46415121	1.E-06	0.15	12q13.13	52.83	NO	rs10506095	1.E-05	20.03
Mdq18	rs27336088	1.E-06	0.16	20q12	40.01	NO	rs6109595	1.E-04	27.15
Mdq19	rs29782631	2.E-06	0.14	11q22.1	100.83	NO	rs948725	2.E-04	23.58
Mdq20	rs36274122	2.E-06	0.14	1q24.3	171.86	NO	rs1538472	5.E-05	73.77

¹Mouse loci from Hadsell et al 2015 (Hadsell et al. 2015); Human loci from Phengeni (http://www.ncbi.nlm.nih.gov/gap/phegeni), and

^cMichailidou et al. (Michailidou et al. 2015; Michailidou et al. 2013)

^ar²,

^bMbp

^dLess than 5Mbp apart; iCOGS data provide larger sample sizes