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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Comp Biochem Physiol C Toxicol Pharmacol. 2017 Dec 5;208:2–11. doi: 10.1016/j.cbpc.2017.11.013

Figure 1. Basal oscillation of gene expression over 24-hour light-dark cycle in Xiphophorus skin, brain and liver.

Figure 1

Genes exhibiting basal oscillating expression patterns over a 24 hr diurnal cycle were identified using the RAIN algorithm (p<0.05). Among the light responsive and reference circadian gene targets on the NanoString panel, 22 genes were identified in skin, 36 genes were identified in brain and 28 genes were identified in liver that showed circadian oscillation. Genes exhibiting oscillating expression patterns identified from different organs were compared to each other. Organ specific oscillating genes and shared oscillating genes among the three organs are categorized into seven groups. Group I, II and III represent genes that were uniquely identified from skin, brain and liver. Group IV represent genes that are shared by all three organs, and Group V, VI and VII represent genes that are shared by two of the three organs. A NanoString nCounter panel was designed to capture gene expression of known light-responsive genes and known circadian rhythm regulator genes. Asterisk (*) highlights previously identified Xiphophorus light-responsive genes.