Skip to main content
. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Comp Biochem Physiol C Toxicol Pharmacol. 2017 Dec 1;208:12–19. doi: 10.1016/j.cbpc.2017.11.008

Table 3.

Summary of Zebrafish Studies Measuring Neurological Effects of Lead (Pb) Exposure

Exposure Duration Age at Exposure Chemical LOEC(ppb) Major Endpoints Reference
3d 0–72 hpf Pb(CH3COO)2 10 Gene expression changes in 89 genes associated with nervous system development Lee and Freeman (2014)
3d 0–72 hpf Pb(CH3COO)2 10 Altered GABA gene expression Wirbisky et al. (2014)
6d 0–144 hpf Pb(CH3COO)2 20 Decreased axon length and decreased locomotion (speed) Zhu et al. (2016)
~3d 2–72 hpf Pb(CH3COO)2 100 No change in Alzheimer’s disease-associated gene, sorl1 Lee et al.(2017)
~5d 2–120 hpf Pb(CH3COO)2 100 Altered color preference (Adults) Bault et al. (2015)
~2d 2–24 hpf Lead nitrate (Pb(NO3)2) 207 Decreased Learning (Adults) Xu et al. (2016)