Table 4.

Summary of Studies Measuring Neurological Effects of Mercury (Hg) Exposure

Exposure Duration	Age of Exposure	Species	Chemical	LOEC(PPB)	Major Endpoints	Reference
1d	Adult	Zebrafish	Mercury chloride (HgCl2)	60	Inhibition of membrane adenosine deaminase	Senger et al. (2010)
54d	Adult	Zebrafish	Methylmercury(MeHg)	80	No change in brain gene expression (qpcr)	Gonzalez et al. (2005)
7d	Adult	Zebrafish	MeHg	119	mt2 gene induction in brain	Gentes et al. (2015)
30d	Adult	Fathead minnow	MeHg	720	Hyperactivity and decreased dopamine	Bridges et al. (2016)
30d	Adult	Fathead minnow	MeHg	870	Hyperactivity & decreased hatching time	Bridges et al. (2016)
56d	Adult	Zebrafish	MeHg	5000	Accumulation in Brain	Amlund et al. (2015)
1d	Adult	Zebrafish	MeHg	5000	Hyperactivity and decreased serotonin	Maximino et al. (2011)
30d	Adult	Fathead minnow	MeHg	5500	Delayed hatching and increased mortality	Bridges et al. (2016)
56d	Adult	Zebrafish	MeHg	10000	Altered proteins associated with gap junction signaling, oxidative phosphorylation, and mitochondrial dysfunction	Rasinger et al. (2017)
56d	Adult	Zebrafish	MeHg	10000	Accumulation in Brain	Amlund et al. (2015)
62d	Adult	Zebrafish	MeHg	11001	mt2 protein increase in brain	Gentes et al. (2015)
49d	Adult	Zebrafish	MeHg	13000	Brain mitochondrial respiration (unaffected)	Bourdineaud et al. (2013)
30d	Adult & Embryo	Fathead minnow	MeHg	720	Hyperactivity and decreased dopamine	Cambier et al. (2012)
~1d	4–24 hpf	Zebrafish	MeHg	3	Adult visual deficit	Weber et al. (2008)
~3d	6 hpf – 72 hpf	Zebrafish	MeHg	10	Decreased neural tube cell proliferation	Hassan et al. (2012)
~3d	5 hpf – 72 hpf	Zebrafish	HgCl2	27	Hyperactivity and mortality	Abu Bakar et al. (2016)
~3d	6 hpf – 72 hpf	Zebrafish	MeHg	50	Delayed hatching	Hassan et al. (2012)
1d	48 hpf – 72 hpf	Zebrafish	MeHg	60	Decrease in head size & alteration of cAMP signaling pathway	Ho et al. (2013)
~3d	6 hpf – 72 hpf	Zebrafish	MeHg	100	Mortality	Hassan et al. (2012)
2d	2–4 dpf	Zebrafish	MeHg	136	Accumulation in photoreceptors in retina and pineal gland	Korbas et al. (2013)
10m	5 dpf	Zebrafish	HgCl2	13576	Accumulation in Brain	Bera et al. (2014)