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. 2018 Apr 30;11:136. doi: 10.3389/fnmol.2018.00136

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Copyright © 2018 Fainstein and Ben-Hur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hippocampal protection of allogeneic NPC grafts is not mediated by CD200 expression. To investigate the hippocampal trait of immune–privilege, we examined the fate of transplanted BrdU-labeled CD200KO NPCs or wt NPCs (n = 7 mice per group). No difference was detected in the survival of CD200KO (A) vs. wt (D) NPCs in the hippocampus (P = 0.42 by student T test). No significant difference was observed in the minor IBA-1+ and CD3+ immune response toward CD200KO NPC grafts (B,C enlargements) and wt NPC grafts (E,F enlargement). Thus, hippocampal immune privilege is restricted to NPC grafts, regardless of CD200 expression. The CA1 and dentate gyrus (DG) regions are shown for purpose of orientation. Scale Bar: (A,B) and (D,E) 300 μm, (C,F) 120 μm.